Of course those who want to make the total amount of indigenous American Indians that died because of Europeans will invoke the word ‘Genocide’. While the numbers are unclear it has been repeatedly estimated that some 20 million in the southeast were killed by small pox in a 10 year period. That was about 90% of the indigenous Mexican population.
While their was most certainly the intentional use of ‘infected’ blankets that could most be pointed to as an intentional cause of death, the numbers affected did not come close to what might be called genocidal. The initial numbers of Indians killed by disease we considered unintentional and they, throughout the western hemisphere accounted for the population decimation of 70,80, and 90%'s of various populations.
While their was willful killing, enslavement, dislocation and starvation, those numbers really don’t rise to the definition of ‘genocide’ and the unintentional spread of disease while unfortunate certianly isn’t a ‘genocide’.